General Information

  • ID:  hor006363
  • Uniprot ID:  P01170
  • Protein name:  somatostatin-28
  • Gene name:  sst2
  • Organism:  Lophius americanus (American angler) (Anglerfish)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Lophius (genus), Lophiidae (family), Lophioidei (suborder), Lophiiformes (order), Eupercaria , Percomorphaceae , Euacanthomorphacea , Acanthomorphata , Ctenosquamata , Eurypterygia , Neoteleostei , Euteleosteomorpha (cohort), Clupeocephala , Osteoglossocephalai , Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SVDSTNNLPPRERKAGCKNFYWKGFTSC
  • Length:  28(98-125)
  • Propeptide:  MQCIRCPAILALLALVLCGPSVSSQLDREQSDNQDLDLELRQHWLLERARSAGLLSQEWSKRAVEELLAQMSLPEADVQREAEDASMATGGRMNLERSVDSTNNLPPRERKAGCKNFYWKGFTSC
  • Signal peptide:  MQCIRCPAILALLALVLCGPSVSS
  • Modification:  T23 5-hydroxylysine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Somatostatin inhibits the release of somatotropin.
  • Mechanism:  Somatostatin II may have a different degree of activity or a different type of target cell from somatostatin I.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  17-28
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006363_AF2.pdbhor006363_ESM.pdb

Physical Information

Mass: 368835 Formula: C140H213N41O42S2
Absent amino acids: HIMQ Common amino acids: KNS
pI: 9.46 Basic residues: 5
Polar residues: 13 Hydrophobic residues: 6
Hydrophobicity: -99.29 Boman Index: -7392
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 27.86
Instability Index: 2803.21 Extinction Coefficient cystines: 7115
Absorbance 280nm: 263.52

Literature

  • PubMed ID:  6107860
  • Title:  Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish.
  • PubMed ID:  2857489
  • Title:  Processing of an anglerfish somatostatin precursor to a hydroxylysine-containing somatostatin 28.
  • PubMed ID:  2887572
  • Title:  Post-translational proc